Injectable
drug delivery via liposomes is a delivery
system for injectable drugs in
biomedical field. A liposome is an artificially-prepared spherical vesicle composed
of a lipid bi-layer which can be used as a delivery system for
administration of nutrients and pharmaceutical drugs.
Liposomes are microscopic vesicles composed of one or more lipid membranes
surrounding discrete aqueous compartments. Liposomes can encapsulate
water-soluble drugs in their aqueous spaces and lipid-soluble drugs within the
membrane itself.
There are
four ways by which liposomes release their contents by interacting with cells:
1. adsorption,
2. endocytosis,
3. lipid exchange,
4. or fusion.
The four major factors which effects liposomes’ distribution
and in vivo behavior are mentioned below:
1. Liposomes
tend to leak if cholesterol is not included in the vesicle membrane.
2. Small
liposomes are cleared more slowly than large liposomes.
3. The
half-life of a liposome increases as the lipid dose increases.
4. Charged
liposomal systems are cleared more rapidly than uncharged systems.
Source: http://www.nanopharmaceuticals.org/
According
to new market research report, the global injectable drug delivery market
is expected to reach $43.3 billion by 2017 at a CAGR of 14.0% from 2012 to
2017. The report categorizes the global market by Devices [Disposables
& Reusable, Fillable & Prefilled, Pen, Needle Free & Auto
Injectors], Formulations [Liposomes, Microspheres, & Nanoparticles] &
Geography. It provides the complete analysis of the global injectable drug
delivery market and its forecasts up to 2017.
According
to the report the past decade has seen a significant shift in terms of the
types of approved injectible drugs delivery systems and the type of diseases
they target. This dramatic shift has boosted the liposomes market a marked
increase in the level of drug & device integration which has fostered
several layers of the healthcare sector to change. The report examines the
total liposomes market by key therapeutic, product, market and regulatory
factors for injectable drugs, providing essential insight and forecast
into the implications of this evolving landscape of injectible drug delivery
market.
The liposomes market is also segmented on the basis of its
therapeutic applications like auto immune diseases, hormonal imbalances,
oncology, orphan diseases (Hemophilia, Ribose-5-phosphate isomerase deficiency
(RPI deficiency), Cystic Fibrosis, and Wilson’s disease) and others like pain
management and allergies. Hormonal disorders commanded the largest share and it
is expected to grow at a CAGR of 13.9% to reach $21.6 billion by 2017. The
major geographic markets covered in this report are North America, Europe,
Asia-Pacific, and RoW. North America dominates the liposomes market, followed
by Europe. However, Asian and Latin American countries are the fastest growing
markets due to growing number of cancer and diabetes incidences, and improving
patient compliance.
The
report can be referred here:
http://www.prweb.com/releases/injectable-drug-delivery/market/prweb11510958.htm
http://www.prweb.com/releases/injectable-drug-delivery/market/prweb11510958.htm
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